Afdn - afadin, adherens junction formation factor

Enables cell adhesion molecule binding activity. Involved in cell-cell adhesion mediated by cadherin; establishment of protein localization to plasma membrane; and pore complex assembly. Acts upstream of or within several processes, including adherens junction maintenance; nervous system development; and regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including adherens junction; apical junction complex; and apical part of cell. Part of pore complex. Is expressed in eye; genitourinary system; and nervous system. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]