Meox1 - mesenchyme homeobox 1

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in sclerotome development. Acts upstream of or within positive regulation of transcription by RNA polymerase II and somite specification. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; genitourinary system; heart; and musculoskeletal system. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 2. Orthologous to human MEOX1 (mesenchyme homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]