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中文人类
NQO1 - NAD(P)H Quinone Dehydrogenase 1
Alias:
DTD
QR1
DHQU
DIA4
NMOR1
NMORI
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这个基因是NAD(P)H脱氢酶(醌)家族的一员，编码一个细胞质2-电子还原酶。这个FAD结合蛋白形成同源二聚体，将醌还原为氢醌。这个蛋白的酶活性防止了醌的一电子还原，这会导致产生自由基物种。这个基因的突变与迟发性运动障碍（TD）、暴露于苯后血液毒性风险增加以及对各种形式癌症的敏感性有关。这个蛋白的异常表达在许多肿瘤中可见，也与阿尔茨海默病（AD）有关。交替的转录剪接变异体，编码不同的异构体，已经被表征。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
NQO1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
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Tile View
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Transcript
Length(nt)
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CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
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Abundance
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Interactions
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Regulation
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Name
MGI
Strain of Origin
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References Literature
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