Meis1 - Meis homeobox 1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of myeloid cell differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and lens morphogenesis in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb bud; and sensory organ. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]