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中文小鼠
Mdm4 - transformed mouse 3T3 cell double minute 4
Alias:
Mdmx
4933417N07Rik
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这个基因编码一种蛋白质，已经证明可以负调控肿瘤抑制蛋白p53的活性。纯合子敲除小鼠由于p53依赖的凋亡和细胞周期停滞而表现出胚胎致死性。这个基因的扩增或编码蛋白质的过度表达与一系列人类癌症有关。在X染色体上发现了一个假基因。这个基因的可变剪接产生了多种转录变异体。[由RefSeq, 2014年11月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
Mdm4 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
References Literature
Title
PMID
Journal
Year
IF
