小鼠

Mag - myelin-associated glycoprotein

Alias:
Gma
siglec-4a
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种I型膜蛋白,属于免疫球蛋白样超家族成员。它在髓鞘形成神经胶质细胞中表达,包括中枢神经系统的少突胶质细胞和外周神经系统的雪旺细胞。缺乏编码蛋白的小鼠表达丰富的髓鞘,但遭受长期轴突退化,Ranvier节处的通道和粘附分子分布改变,以及轴突细胞骨架结构改变。虽然不是髓鞘形成的必需,但编码的蛋白增强轴突-髓鞘稳定性,有助于Ranvier节的结构,并调节轴突细胞骨架。可变剪接产生多种转录变异体。[由RefSeq,2016年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
13
12
15748 bp
69.39
9
22

Mag Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
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