Enables identical protein binding activity and porphobilinogen synthase activity. Acts upstream of or within cellular response to interleukin-4 and heme biosynthetic process. Predicted to be located in extracellular space. Predicted to be active in cytosol. Is expressed in several structures, including liver; lung; metanephros; spleen; and yolk sac. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Apr 2022]