Lrp1 - low density lipoprotein receptor-related protein 1

Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of transport. Acts upstream of or within several processes, including apoptotic cell clearance; cholesterol metabolic process; and heart development. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]