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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Sh2b3 - SH2B adaptor protein 3
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码SH2B适配器蛋白家族的一员,该家族在T细胞受体信号传导中扮演重要角色。这个基因在造血干细胞、造血祖细胞、前B细胞和未成熟B细胞以及巨核细胞和肥大细胞中优先表达。在造血干细胞中,编码的蛋白质是自我更新、增殖和凋亡的关键调节因子。缺乏编码的蛋白质的小鼠在脾和骨髓中表现出前B细胞和未成熟B细胞的扩张。可选的剪接导致编码不同异构体的多种转录变异体。[由RefSeq,2015年4月提供]
Related ID:
NCBI:16923
ENSEMBL:ENSMUSG00000042594
UNIPROT:O09039
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
16923
9
9
22163 bp
60.49
4
4
Sh2b3 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Abundance
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Cell-specific RNA expression
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Interactions
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Regulation
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Type
Name
MGI
Strain of Origin
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References Literature
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IF
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