Arhgef1 - Rho guanine nucleotide exchange factor (GEF) 1

Predicted to enable G protein-coupled receptor binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of cell death. Predicted to be located in cytosol and plasma membrane. Is expressed in brain and heart. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]