Lats1 - large tumor suppressor

Predicted to enable several functions, including ATP binding activity; estrogen receptor binding activity; and magnesium ion binding activity. Involved in hormone-mediated signaling pathway; negative regulation of protein localization to nucleus; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in spindle pole. Is expressed in acoustic ganglion; early conceptus; embryo; endolymphatic appendage; and otocyst. Orthologous to human LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Apr 2022]