Mafb - MAF bZIP transcription factor B

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in abducens nerve formation; negative regulation of osteoclast differentiation; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and respiratory gaseous exchange by respiratory system. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Used to study Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Human ortholog(s) of this gene implicated in Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Orthologous to human MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Apr 2022]