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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Klc1 - kinesin light chain 1
Alias:
Kns2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
传统动力蛋白是一种由两个重链和两个轻链组成的四聚分子,沿着微管蛋白将其各种货物运输到正端。重链提供马达活性,而轻链与各种货物结合。该基因编码动力蛋白轻链家族的一员。它通过N-末端结构域与动力蛋白重链结合,六个四肽重复序列(TPR)被认为涉及与囊泡、线粒体和高尔基复合物等货物结合。因此,动力蛋白轻链作为适配器分子而不是真正的马达发挥作用。尽管以前被称为“动力蛋白2”,但该基因不是动力蛋白马达蛋白质的动力蛋白2/动力蛋白重链亚家族的成员。广泛的替代剪接产生了具有不同C-末端的异构体,建议它们结合不同的货物;然而,其中一些变异体的全长性质尚未确定。[由RefSeq,2008年7月提供]
Related ID:
NCBI:16593
ENSEMBL:ENSMUSG00000021288
UNIPROT:O88447
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
16593
21
16
49410 bp
Unknown
6
13
Klc1 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
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Cell-specific RNA expression
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Interactions
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Acting
Regulation
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Residues
Reference
Score
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Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available
References Literature
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PMID
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Year
IF
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