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中文人类
DDIT3 - DNA Damage Inducible Transcript 3
Alias:
CHOP
CEBPZ
CHOP10
CHOP-10
GADD153
AltDDIT3
C/EBPzeta
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这个基因编码一个CCAAT/增强子结合蛋白（C/EBP）家族的转录因子成员。该蛋白作为显性负抑制因子，通过与其他C/EBP成员如C/EBP和LAP（肝脏激活蛋白）形成异二聚体，防止它们的DNA结合活性。该蛋白与脂肪生成和红细胞生成有关，由内质网应激激活，并促进凋亡。这个基因与染色体16上的FUS或染色体22上的EWSR1融合，通过易位产生嵌合蛋白，形成粘液样脂肪肉瘤或Ewing肉瘤。已经识别出多种可变剪接转录变异体，编码具有不同长度的两种异构体。[由RefSeq，2010年8月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
DDIT3 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
