Il1rap - interleukin 1 receptor accessory protein

Enables interleukin-1 receptor activity; interleukin-33 receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Acts upstream of or within cytokine-mediated signaling pathway; positive regulation of dendrite development; and positive regulation of synapse assembly. Located in glutamatergic synapse. Is expressed in dorsal aorta; future brain; genitourinary system; liver; and ventral grey horn. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2022]