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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Ikbkb - inhibitor of kappaB kinase beta
Alias:
IKK2
IKK-2
IKK[b]
IKKbeta
IKK-beta
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
激活IkappaB激酶活性和蛋白质磷酸酶结合活性。参与肽基-丝氨酸磷酸化和肿瘤坏死因子介导的信号传导途径。在B细胞稳态的上游或内部发挥作用;阳离子通道活动的正向调节;和钠离子运输的正向调节。位于质膜的细胞质侧。是CD40受体复合物的一部分。在多个结构中表达,包括泌尿系统和肌肉组织。用于研究免疫缺陷15A。这个基因的人类同源物与乳腺癌、联合免疫缺陷(多种)、皮炎、前列腺癌(多种)和2型糖尿病有关。与人类的IKBKB(核因子kappa B激酶亚基β的抑制剂)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:16150
ENSEMBL:ENSMUSG00000031537
UNIPROT:O88351
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
16150
8
21
47385 bp
86.69
16
21
Ikbkb Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
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