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中文人类
DAB2 - DAB Adaptor Protein 2
Alias:
DOC2
DOC-2
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这个基因编码一种有丝分裂原响应的磷酸蛋白。它在正常的卵巢上皮细胞中表达，但在卵巢癌细胞系中下调或缺失，提示其作为肿瘤抑制因子的作用。这个蛋白通过其C端的富含脯氨酸序列与适配蛋白GRB2的SH3结构域结合，GRB2将酪氨酸激酶受体与SOS（Ras的鸟苷酸交换因子）结合，从而可能通过与SOS竞争结合GRB2来调节生长因子/Ras通路。已发现这个基因的不同剪接转录变异体编码不同的异构体。[RefSeq，2011年10月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
DAB2 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
