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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Igf1 - insulin-like growth factor 1
Alias:
Igf-1
Igf-I
C730016P09Rik
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码胰岛素样生长因子(IGF)家族的一员,该家族蛋白质在胎儿和出生后生活中促进生长和发展。这个基因主要在肝脏中表达,其编码的蛋白质经过蛋白水解加工,生成一个由二硫键连接的成熟多肽。将这个基因在鼠中转基因破坏导致出生后存活率降低和严重的生长迟缓。缺乏编码的蛋白质的小鼠表现出普遍的器官发育不良,包括中枢神经系统发育不全和骨骼、肌肉和生殖系统的发育缺陷。可变剪接导致多个转录变异体,它们编码不同的可能经历类似加工以生成成熟蛋白质的异构体。[由RefSeq,2015年9月提供]
Related ID:
NCBI:16000
ENSEMBL:ENSMUSG00000020053
UNIPROT:P05017
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
16000
20
4
78783 bp
17.09
16
17
Igf1 Genetics information (+)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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