Hspa8 - heat shock protein 8

Enables ATP hydrolysis activity; phosphatidylserine binding activity; and unfolded protein binding activity. Involved in several processes, including chaperone-mediated protein folding; late endosomal microautophagy; and positive regulation by host of viral genome replication. Acts upstream of or within several processes, including chaperone cofactor-dependent protein refolding; clathrin coat disassembly; and positive regulation of mRNA splicing, via spliceosome. Located in several cellular components, including extracellular exosome; glycinergic synapse; and photoreceptor ribbon synapse. Is active in presynapse. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; brain; eye; and forelimb long bone. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Apr 2022]