Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. Involved in ductus arteriosus closure. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; choroid plexus; humerus cartilage condensation; nose; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]