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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Gzmb - granzyme B
Alias:
GZB
CCP1
Ctla1
Ctla-1
CCP-1/C11
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码颗粒酶亚家族蛋白质的一员,这是丝氨酸蛋白酶肽酶S1家族的一部分。编码的前原蛋白被自然杀手(NK)细胞和细胞毒性T淋巴细胞(CTLs)分泌,并通过蛋白水解过程生成活性蛋白酶,从而诱导目标细胞凋亡。这种蛋白质还处理细胞因子并降解细胞外基质蛋白,这些作用与慢性炎症和伤口愈合有关。缺乏这个基因功能副本的小鼠表现出免疫细胞介导的细胞溶解受损。[由RefSeq,2016年9月提供]
Related ID:
NCBI:14939
ENSEMBL:ENSMUSG00000015437
UNIPROT:P04187
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
14939
1
5
3499 bp
27.47
9
14
Gzmb Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
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