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中文人类
CTLA4 - Cytotoxic T-lymphocyte Associated Protein 4
Alias:
CD
GSE
GRD4
ALPS5
CD152
CTLA-4
IDDM12
CELIAC3
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这个基因是免疫球蛋白超家族的成员，编码一种将抑制信号传递到T细胞的蛋白质。该蛋白质包含一个V结构域，一个跨膜结构域和一个胞质尾。已表征了编码不同异构体的替代转录剪接变体。膜结合的异构体作为通过二硫键互连的同源二聚体发挥作用，而可溶性的异构体作为单体发挥作用。这个基因的突变与胰岛素依赖性糖尿病、格雷夫斯病、桥本甲状腺炎、乳糜泻病、系统性红斑狼疮、甲状腺相关眼眶病以及其他自身免疫性疾病有关。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
CTLA4 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
