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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Hspa5 - heat shock protein 5
Alias:
Bip
Sez7
mBiP
Grp78
SEZ-7
Hsce70
baffled
D2Wsu17e
D2Wsu141e
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
能够使错误折叠的蛋白质结合活性并结合核糖体。参与几个过程,包括IRE1介导的未折叠蛋白质应答;小脑发育;以及蛋白质泛素化的正向调节。在几个过程的上游或内部发挥作用,包括细胞对白细胞介素-4的反应;转化生长因子β受体信号通路负向调节;以及毒素运输。位于几个细胞组件中,包括细胞表面;内质网;以及内质网-高尔基中间复合体。是内质网分子伴侣复合物的一部分。在几个结构中表达,包括消化系统;大脑;眼睛;生殖泌尿系统;以及肌肉骨骼系统。该基因的人类同源物与多巴胺β-羟化酶缺乏症有关。与人类HSPA5(热休克蛋白家族A(Hsp70)成员5)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:14828
ENSEMBL:ENSMUSG00000026864
UNIPROT:P20029
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
14828
2
9
4440 bp
72.42
10
31
Hspa5 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
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Name
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