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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Grin2b - glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Alias:
NR2B
GluN2B
Nmdar2b
GluRepsilon2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
调节突触后膜电位的NMDA谷氨酸受体活性;钙通道活性;和神经递质受体活性。参与树突棘维持的负调控和神经元死亡的正调控。在几个过程的上游或内部发挥作用,包括行为恐惧反应;参与疼痛感知感的机械刺激检测;和学习或记忆。位于几个细胞组件中,包括胞质囊泡;溶酶体;和突触膜。NMDA选择性谷氨酸受体复合物的组成部分。在谷氨酸能突触中活跃。是突触后密度膜的集成组件。在几个结构中表达,包括脂肪组织;中枢神经系统;眼睛;肠道;和生殖系统。这个基因的人类同源物涉及几种疾病,包括酒精使用障碍;常染色体显性非综合征性智力障碍6;双相障碍;发育性和癫痫性脑病27;和神经退行性疾病(多种)。与人类GRIN2B(谷氨酸离子型受体NMDA型亚单位2B)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:14812
ENSEMBL:ENSMUSG00000030209
UNIPROT:Q01097
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
14812
7
15
460440 bp
165.96
22
17
Grin2b Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
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