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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Gria4 - glutamate receptor, ionotropic, AMPA4 (alpha 4)
Alias:
GluA4
Glur4
spkw1
GluR-D
Glur-4
Gluralpha4
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
谷氨酸受体是哺乳动物大脑中主要的兴奋性神经递质受体,在各种正常的神经生理过程中被激活。这些受体是异质性蛋白质复合物,由多个亚基组成,排列形成配体门控离子通道。谷氨酸受体的分类基于它们不同药理学激动剂的激活。这个基因编码的亚基属于一个AMPA(α-氨基-3-羟基-5-甲基-4-异唑丙酸)敏感谷氨酸受体家族,并受到RNA编辑的影响(AGA->GGA;R->G)。这个基因的可变剪接导致编码不同异构体的转录变异体,它们在信号传导特性上可能有所不同。[由RefSeq,2008年7月提供]
Related ID:
NCBI:14802
ENSEMBL:ENSMUSG00000025892
UNIPROT:Q9Z2W8
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
14802
9
17
378358 bp
100.85
12
10
Gria4 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
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CDS(bp)
Protein
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Type
Name
MGI
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