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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Gria2 - glutamate receptor, ionotropic, AMPA2 (alpha 2)
Alias:
GluA2
Glur2
GluR-B
Glur-2
gluR-K2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
谷氨酸受体是哺乳动物大脑中主要的兴奋性神经递质受体,在各种正常的神经生理过程中被激活。这个基因产物属于一个对α-氨基-3-羟基-5-甲基-4-异氧唑丙酸(AMPA)敏感的谷氨酸受体家族,并作为配体激活的阳离子通道发挥作用。这些通道由4个相关亚单位组装而成,分别是Gria1-4。这个基因编码的亚单位(Gria2)在第二个跨膜结构域内受到RNA编辑(CAG->CGG; Q->R)的影响,这被认为使通道对Ca(2+)不可渗透。这个基因的替代剪接,导致编码不同异型体的转录变异体(包括在信号传导特性上有所差异的翻转和翻转异型体)已经被注意到。[由RefSeq,2008年7月提供]
Related ID:
NCBI:14800
ENSEMBL:ENSMUSG00000033981
UNIPROT:P23819
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
14800
6
16
122778 bp
Unknown
20
--
Gria2 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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Length(nt)
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* This data comes from NCBI.
Gene Expression
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