Gfi1b - growth factor independent 1B

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in regulation of histone methylation and regulation of myeloid cell differentiation. Predicted to be located in nuclear matrix; nucleoplasm; and plasma membrane. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in eye; gut; immune system; liver; and testis. Human ortholog(s) of this gene implicated in gray platelet syndrome and platelet-type bleeding disorder 17. Orthologous to human GFI1B (growth factor independent 1B transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]