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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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人类
MAPK14 - Mitogen-activated Protein Kinase 14
Alias:
RK
p38
CSBP
EXIP
Mxi2
CSBP1
CSBP2
CSPB1
PRKM14
PRKM15
SAPK2A
p38ALPHA
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是MAP激酶家族的成员。MAP激酶作为多个生物化学信号的整合点,参与多种细胞过程,如增殖、分化、转录调节和发育。这个激酶受到各种环境压力和前炎症细胞因子的激活。激活需要其被MAP激酶激酶(MKKs)磷酸化,或者由MAP3K7IP1/TAB1蛋白与这个激酶的相互作用触发的自磷酸化。这个激酶的底物包括转录调节子ATF2、MEF2C和MAX、细胞周期调节剂CDC25B和肿瘤抑制子p53,这表明这个激酶在应激相关转录和细胞周期调节中,以及在基因毒性压力反应中的作用。已经报道了这个基因的四个可变剪接转录变异体,它们编码不同的异构体。[由RefSeq,2008年7月提供]
Related ID:
NCBI:1432
ENSEMBL:ENSG00000112062
HGNC:6876
UNIPROT:Q16539
OMIM:600289
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
1432
14
12
96407 bp
41.29
3
--
19
77
MAPK14 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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