人类

MAPK14 - Mitogen-activated Protein Kinase 14

Alias:
RK
p38
CSBP
EXIP
Mxi2
CSBP1
CSBP2
CSPB1
PRKM14
PRKM15
SAPK2A
p38ALPHA
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是MAP激酶家族的成员。MAP激酶作为多个生物化学信号的整合点,参与多种细胞过程,如增殖、分化、转录调节和发育。这个激酶受到各种环境压力和前炎症细胞因子的激活。激活需要其被MAP激酶激酶(MKKs)磷酸化,或者由MAP3K7IP1/TAB1蛋白与这个激酶的相互作用触发的自磷酸化。这个激酶的底物包括转录调节子ATF2、MEF2C和MAX、细胞周期调节剂CDC25B和肿瘤抑制子p53,这表明这个激酶在应激相关转录和细胞周期调节中,以及在基因毒性压力反应中的作用。已经报道了这个基因的四个可变剪接转录变异体,它们编码不同的异构体。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
14
12
96407 bp
41.29
3
--
19
77

MAPK14 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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