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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Fst - follistatin
Alias:
FS
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质与激活素以及其他转化生长因子β家族成员结合并负调控,防止细胞无控制地增殖。这个蛋白质还包含一个肝素结合序列。它在许多合成激活素的组织中表达,并通过与细胞表面的附着从循环中清除激活素。可变剪接产生多种编码多种蛋白质异型的转录变异体,包括FST315和FST288,它们的C端不同。另一种异构体FST303被认为是通过FST315的蛋白水解切割产生的。这些异构体在它们的定位和结合肝素的能力上有所不同。虽然FST315是一种循环蛋白质,但FST288是组织结合的,FST303是生殖特异性。虽然删除所有异构体会导致胚胎致死,但仅表达FST288就足以支持胚胎发育,但产生的小鼠具有生育缺陷。[RefSeq,2014年8月提供]
Related ID:
NCBI:14313
ENSEMBL:ENSMUSG00000021765
UNIPROT:P47931
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
14313
4
6
6725 bp
37.87
7
11
Fst Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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Transcript
Length(nt)
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CDS(bp)
Protein
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* This data comes from NCBI.
Gene Expression
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Name
MGI
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References Literature
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