小鼠

Fhit - fragile histidine triad gene

Alias:
Fra14A2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码HIT家族蛋白质的一员,其特征是存在组氨酸三联序列。编码的蛋白质是一种二腺苷三磷酸水解酶,能将P(1)-P(3)-双(5'-腺苷)三磷酸(Ap3A)切割成AMP和ADP。这个基因座非常脆弱,已在不同类型癌症中发现改变。缺乏编码蛋白质的小鼠对自发生成的和诱导的肿瘤的易感性增加。在敲除小鼠中异位表达编码的蛋白质可以抑制肿瘤的发展。选择性剪接产生多种转录变异体,编码不同的异构体。[RefSeq,2015年4月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
10
10
1612003 bp
17.23
4
8

Fhit Genetics information (+)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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