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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Fhit - fragile histidine triad gene
Alias:
Fra14A2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码HIT家族蛋白质的一员,其特征是存在组氨酸三联序列。编码的蛋白质是一种二腺苷三磷酸水解酶,能将P(1)-P(3)-双(5'-腺苷)三磷酸(Ap3A)切割成AMP和ADP。这个基因座非常脆弱,已在不同类型癌症中发现改变。缺乏编码蛋白质的小鼠对自发生成的和诱导的肿瘤的易感性增加。在敲除小鼠中异位表达编码的蛋白质可以抑制肿瘤的发展。选择性剪接产生多种转录变异体,编码不同的异构体。[RefSeq,2015年4月提供]
Related ID:
NCBI:14198
ENSEMBL:ENSMUSG00000060579
UNIPROT:O89106
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
14198
10
10
1612003 bp
17.23
4
8
Fhit Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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