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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
F10 - coagulation factor X
Alias:
fX
Cf10
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码因子X,既是内在和外在血液凝固途径的组成部分。编码的蛋白质是一种酶原,在维生素K依赖的方式下进行进一步加工,生成成熟的因子X,一个由二硫键连接的重链和轻链组成的异二聚体。成熟的因子X被蛋白水解酶激活,可以是因子IXa(内在途径)或因子VIIa(外在途径),形成因子Xa丝氨酸内肽酶。活化的因子Xa催化凝血酶原转化为凝血酶。编码的蛋白质完全缺乏会导致小鼠死亡。小鼠中编码的蛋白质严重缺乏会导致年龄依赖的铁沉积和心脏纤维化。可变剪接产生多个转录变异体,编码不同的异构体。[由RefSeq,2015年8月提供]
Related ID:
NCBI:14058
ENSEMBL:ENSMUSG00000031444
UNIPROT:O88947
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
14058
2
9
19369 bp
54.02
8
13
F10 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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Transcript
Length(nt)
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* This data comes from NCBI.
Gene Expression
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