Enables integrin binding activity. Involved in several processes, including early endosome to late endosome transport; embryo implantation; and membrane raft assembly. Acts upstream of or within positive regulation of integrin-mediated signaling pathway. Located in Golgi apparatus; apical plasma membrane; and cell surface. Colocalizes with cytoplasmic vesicle; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; medulla oblongata lateral wall; naris epithelium; respiratory system; and ventricular layer. Used to study placental insufficiency. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]