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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Eif4e - eukaryotic translation initiation factor 4E
Alias:
If4e
eIF-4E
EG668879
Eif4e-ps
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个真核翻译起始因子4F复合体的成分,该复合体识别信使RNA 5'端的7-甲基鸟苷帽结构。编码的蛋白质通过将核糖体招募到5'帽结构中辅助翻译起始。这个蛋白质与4F复合体的结合是翻译起始的限速步骤。这个基因作为一个原癌基因,其表达和激活与转化和肿瘤发生有关。它还与自闭症谱系障碍有关。一致地,这个基因的敲除导致神经络素(与自闭症谱系障碍相关的突触后蛋白)的翻译增加。这个基因的假基因位于其他染色体上。可选的剪接导致多个转录变异体。[由RefSeq,2015年9月提供]
Related ID:
NCBI:13684
ENSEMBL:ENSMUSG00000028156
UNIPROT:P63073
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
13684
5
8
33506 bp
25.05
8
36
Eif4e Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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