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Eif4e - eukaryotic translation initiation factor 4E

Alias:
If4e
eIF-4E
EG668879
Eif4e-ps
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个真核翻译起始因子4F复合体的成分,该复合体识别信使RNA 5'端的7-甲基鸟苷帽结构。编码的蛋白质通过将核糖体招募到5'帽结构中辅助翻译起始。这个蛋白质与4F复合体的结合是翻译起始的限速步骤。这个基因作为一个原癌基因,其表达和激活与转化和肿瘤发生有关。它还与自闭症谱系障碍有关。一致地,这个基因的敲除导致神经络素(与自闭症谱系障碍相关的突触后蛋白)的翻译增加。这个基因的假基因位于其他染色体上。可选的剪接导致多个转录变异体。[由RefSeq,2015年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
5
8
33506 bp
25.05
8
36

Eif4e Genetics information (+)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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