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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
E2f1 - E2F transcription factor 1
Alias:
E2F-1
mKIAA4009
Tg(Wnt1-cre)2Sor
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
激活DNA结合转录因子活性,并调节顺式调控区域的转录活性。参与脂肪细胞分化的负调控,脂肪细胞增殖的负调控,以及DNA模板的转录。在多个过程的上游或内部发挥作用,包括anoikis、p53类介体的内在凋亡信号通路和晶状体纤维细胞凋亡过程。位于染色质、细胞质和细胞核中。是转录调节复合物的一部分。在包括消化系统、中枢神经系统、生殖泌尿系统、肺和视网膜在内的几个结构中表达。用于研究Sjogren's综合征和1型糖尿病。此基因的人类同源物与肺癌、肺小细胞癌、肺鳞状细胞癌、胰腺癌和胰腺癌有关。与人类E2F1(E2F转录因子1)正交。[由基因组资源联盟,2022年4月提供]
Related ID:
NCBI:13555
ENSEMBL:ENSMUSG00000027490
UNIPROT:Q61501
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
13555
2
7
10493 bp
46.32
8
17
E2f1 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Type
Name
MGI
Strain of Origin
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IF
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