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E2f1 - E2F transcription factor 1

Alias:
E2F-1
mKIAA4009
Tg(Wnt1-cre)2Sor
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
激活DNA结合转录因子活性,并调节顺式调控区域的转录活性。参与脂肪细胞分化的负调控,脂肪细胞增殖的负调控,以及DNA模板的转录。在多个过程的上游或内部发挥作用,包括anoikis、p53类介体的内在凋亡信号通路和晶状体纤维细胞凋亡过程。位于染色质、细胞质和细胞核中。是转录调节复合物的一部分。在包括消化系统、中枢神经系统、生殖泌尿系统、肺和视网膜在内的几个结构中表达。用于研究Sjogren's综合征和1型糖尿病。此基因的人类同源物与肺癌、肺小细胞癌、肺鳞状细胞癌、胰腺癌和胰腺癌有关。与人类E2F1(E2F转录因子1)正交。[由基因组资源联盟,2022年4月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
2
7
10493 bp
46.32
8
17

E2f1 Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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