Enables thiol-dependent deubiquitinase. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; integumental system; reproductive system; and thymus. Orthologous to several human genes including USP17L2 (ubiquitin specific peptidase 17 like family member 2). [provided by Alliance of Genome Resources, Apr 2022]