小鼠

Dnmt1 - DNA methyltransferase (cytosine-5) 1

Alias:
Dnmt
MCMT
Met1
Cxxc9
MTase
Met-1
Dnmt1o
m.MmuI
MommeD2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个优先在半甲基化DNA中的CpG残基的胞嘧啶上甲基化的甲基转移酶,在DNA复制过程中生成完全甲基化的CpG碱基对。这种酶在多种细胞过程中发挥作用,包括细胞周期调节、DNA修复和端粒维持。编码的蛋白质由具有核定位序列和复制叉靶向结构的N端结构域、一个DNA结合CXXC结构域、两个bromo相邻同源结构域和一个C端催化结构域组成。小鼠胚胎干细胞中这个基因的突变是可行的,但当引入生殖系时,会导致隐性致死表型,突变胚胎显示生长受抑制和发育缺陷。可变剪接产生多种转录变异体。[RefSeq,2015年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
7
39
52584 bp
183.19
28
35

Dnmt1 Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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