Ddit3 - DNA-damage inducible transcript 3

Enables several functions, including cAMP response element binding protein binding activity; protein heterodimerization activity; and transcription regulator inhibitor activity. Involved in several processes, including blood vessel maturation; intrinsic apoptotic signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within ER overload response; negative regulation of fat cell differentiation; and sensory perception of sound. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Apr 2022]