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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Plk3 - polo like kinase 3
Alias:
Cnk
Fnk
PRK
PLK-3
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个高度保守的polo样激酶家族的成员,该家族成员的特征是氨基端催化域和羧基端双功能polo盒结构域,后者作为底物结合基序和细胞定位信号。Polo样激酶主要与细胞周期调节有关。在鼠中,据报道,该蛋白在间期定位到核仁,但在有丝分裂期间不可检测,因为在有丝分裂前期核仁解体。该蛋白在胞质分裂之前重新定位到核仁,并在间期G1期的峰值水平被检测到。这个基因与进入S期的调节有关,通过RNA干扰诱导的减少导致重新进入细胞周期失败。缺乏这个基因的小鼠在老年时体重增加和肿瘤发展增加。可选的剪接导致多个转录变异体。[RefSeq,2015年9月提供]
Related ID:
NCBI:12795
ENSEMBL:ENSMUSG00000028680
UNIPROT:Q60806
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
12795
3
15
5393 bp
Unknown
7
2
Plk3 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
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CDS(bp)
Protein
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Cell-specific RNA expression
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Name
MGI
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References Literature
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IF
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