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中文小鼠
Tpp1 - tripeptidyl peptidase I
Alias:
Cln2
LPIC
TPP-1
TPP-I
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这个基因编码一种溶酶体的丝氨酸蛋白酶，能够从蛋白质底物中切割N-末端的三肽。编码的预前蛋白经历自催化加工，生成成熟的酶。缺乏编码蛋白的小鼠表现出进行性的神经退化和显著缩短的寿命。在细胞水平上，缺乏编码蛋白的小鼠表现出自荧光脂质色素积累。这个基因的人类同源基因的突变导致典型的晚婴儿期神经鞘脂黄病。[RefSeq, Nov 2015提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
Tpp1 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
References Literature
Title
PMID
Journal
Year
IF
