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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Cldn4 - claudin 4
Alias:
Cep-r
Cpetr
Cpetr1
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个claudin家族的成员。Claudins是整合膜蛋白,是紧密连接链的组成部分。紧密连接链作为物理屏障,防止溶质和水分自由通过上皮或内皮细胞板之间的胞间间隙。它们还在维持细胞极性和信号传导中起到关键作用。这个基因编码的蛋白质是梭状芽孢杆菌肠毒素(CPE)的高亲和力受体,由梭状芽孢杆菌产生,与CPE相互作用通过在质膜上形成小孔增加膜通透性。这个蛋白质增强肺泡上皮屏障功能,并在急性肺损伤中被诱导表达。它在胰腺和卵巢癌症中高表达。[RefSeq,2010年8月提供]
Related ID:
NCBI:12740
ENSEMBL:ENSMUSG00000047501
UNIPROT:O35054
Basic Information
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Transcripts
Exons
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MW (kDa)
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Reference
12740
1
1
1812 bp
22.34
4
13
Cldn4 Genetics information (-)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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