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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Cldn2 - claudin 2
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个claudin家族的成员。Claudins是整合膜蛋白,是紧密连接链的组成部分。紧密连接链作为物理屏障,防止溶质和水分自由通过上皮或内皮细胞片之间的胞间空间。它们还在维持细胞极性和信号传导方面发挥关键作用。敲除这个基因的小鼠外观、活动、生长和行为正常,但在肾近端小管的漏水和阳离子选择性胞间通透性方面有缺陷。这个基因和另一个家族成员Cldn12编码的蛋白质对维生素D依赖的肠细胞间Ca2+吸收也至关重要。[RefSeq,2010年8月提供]
Related ID:
NCBI:12738
ENSEMBL:ENSMUSG00000047230
UNIPROT:O88552
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
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Reference
12738
6
2
10584 bp
24.48
4
9
Cldn2 Genetics information (+)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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