Clcn5 - chloride channel, voltage-sensitive 5

Predicted to enable identical protein binding activity; solute:proton antiporter activity; and voltage-gated chloride channel activity. Acts upstream of or within endocytosis. Located in apical part of cell and endosome. Is expressed in early conceptus; heart; metanephros; and oocyte. Used to study Dent disease. Human ortholog(s) of this gene implicated in Dent disease; X-linked nephrolithiasis type I; X-linked recessive hypophosphatemic rickets; and low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Orthologous to human CLCN5 (chloride voltage-gated channel 5). [provided by Alliance of Genome Resources, Apr 2022]