人类

PLK3 - Polo Like Kinase 3

Alias:
CNK
FNK
PRK
PLK-3
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是高度保守的波洛样激酶家族丝氨酸/苏氨酸激酶家族的成员。这个家族的成员以氨基末端激酶域和羧基末端双分体波洛盒域为特征,该域作为底物结合模式和细胞定位信号。波洛样激酶是细胞周期进展的重要调节者。这个基因也被认为在应激反应和双链断裂修复中起作用。在人类细胞系中,这个蛋白质据报道以微管依赖的方式与中心体结合,在有丝分裂期间,该蛋白质被定位到有丝分裂装置。表达一个激酶缺陷突变体会导致由于微管动力学变化和有丝分裂停滞而引起的细胞形态异常,然后是凋亡。[由RefSeq提供,2015年9月]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
3
15
5614 bp
71.63
38
--
7
32

PLK3 Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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