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Cdkn2c - cyclin dependent kinase inhibitor 2C

Alias:
p18
INK4c
p18-INK6
p18INK4c
p18-INK4c
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码的蛋白质是周期蛋白依赖的激酶(cdk)抑制剂INK4家族的成员,包含五个ankyrin重复序列。这个蛋白质与Cdk4和Cdk6相互作用,抑制它们的激酶活性,防止它们与D型周期蛋白的相互作用,从而负调控细胞分裂。这个基因在各种组织中的表达存在差异,并且受到细胞周期的调控。这个基因的缺失可能导致肿瘤生长。在G2/M期表达达到最大值。选择性剪接和启动子使用导致多个转录变异体。[RefSeq,2014年8月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
2
3
5881 bp
18.07
4
9

Cdkn2c Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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