Cdkn2b - cyclin dependent kinase inhibitor 2B

Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and spleen development. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; immune system; lung; and retina. Human ortholog(s) of this gene implicated in carcinoma (multiple); erythema infectiosum; hematologic cancer (multiple); open-angle glaucoma; and urinary bladder cancer. Orthologous to human CDKN2B (cyclin dependent kinase inhibitor 2B). [provided by Alliance of Genome Resources, Apr 2022]