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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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人类
CCR8 - C-C Motif Chemokine Receptor 8
Alias:
CY6
TER1
CCR-8
CKRL1
CDw198
CMKBR8
GPRCY6
CMKBRL2
CC-CKR-8
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码β趋化因子受体家族的一员,预测是一个类似于G蛋白偶联受体的七跨膜蛋白。趋化因子及其受体对于各种细胞迁移到炎症部位非常重要。这个受体蛋白在胸腺中优先表达。已经识别出I-309、胸腺激活调节细胞因子(TARC)和巨噬细胞炎性蛋白-1β(MIP-1β)作为这个受体的配体。这个受体及其配体的研究提示其在调节单核细胞趋化作用和胸腺细胞凋亡中发挥作用。更具体地说,这个受体可能有助于激活T细胞在抗原挑战部位和淋巴组织特化区域中的正确定位。这个基因位于趋化因子受体基因簇区域。[由RefSeq,2008年7月提供]
Related ID:
NCBI:1237
ENSEMBL:ENSG00000179934
HGNC:1609
UNIPROT:P51685
OMIM:601834
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
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Reference
1237
1
2
3972 bp
40.84
12
--
9
11
CCR8 Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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