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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Casp4 - caspase 4, apoptosis-related cysteine peptidase
Alias:
Caspl
ich-3
CASP-4
Casp11
CASP-11
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
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References Literature
这个基因编码半胱氨酸蛋白酶家族成员,在凋亡、细胞迁移和炎症反应中扮演重要角色。编码的蛋白质通过巨噬细胞在细菌感染后调节促炎性细胞因子的产生。缺乏编码蛋白质的小鼠对脂多糖诱导的内毒素性休克具有抵抗力。已经描述了一种涵盖剪接接受器接合部的5-bp缺失,导致某些小鼠品系中的交替剪接和较短的无功能异构体。尽管其正式命名是“caspase 4, 凋亡相关半胱氨酸肽酶”,但这个基因及其编码的蛋白质历史上被称为caspase 11。这个基因位于染色体9上三个caspase基因的簇中。[由RefSeq,2015年4月提供]
Related ID:
NCBI:12363
ENSEMBL:ENSMUSG00000033538
UNIPROT:P70343
Basic Information
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Transcripts
Exons
Length
MW (kDa)
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12363
9
9
27976 bp
42.74
12
29
Casp4 Genetics information (+)
GRCm39
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* This data comes from NCBI.
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