人类

CCR7 - C-C Motif Chemokine Receptor 7

Alias:
BLR2
EBI1
CCR-7
CD197
CDw197
CMKBR7
CC-CKR-7
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是G蛋白偶联受体家族的成员。这个受体被鉴定为受Epstein-Barr病毒(EBV)诱导的基因,被认为是对B淋巴细胞中EBV效应的调节剂。这个受体在各种淋巴组织中表达,并激活B和T淋巴细胞。已经证明它可以控制记忆T细胞向发炎组织的迁移,以及刺激树突状细胞的成熟。已经报道,化学诱导体(C-C基序)配体19(CCL19/ECL)是这个受体的特异性配体。这个受体介导的信号调节淋巴结中T细胞的稳态,也可能在T细胞的激活和极化以及慢性炎症发病机制中发挥作用。这个基因的可变剪接导致多个转录变异体。[RefSeq,2014年9月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5
3
11704 bp
42.87
11
--
9
5

CCR7 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Tutorials
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