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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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人类
CCR7 - C-C Motif Chemokine Receptor 7
Alias:
BLR2
EBI1
CCR-7
CD197
CDw197
CMKBR7
CC-CKR-7
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是G蛋白偶联受体家族的成员。这个受体被鉴定为受Epstein-Barr病毒(EBV)诱导的基因,被认为是对B淋巴细胞中EBV效应的调节剂。这个受体在各种淋巴组织中表达,并激活B和T淋巴细胞。已经证明它可以控制记忆T细胞向发炎组织的迁移,以及刺激树突状细胞的成熟。已经报道,化学诱导体(C-C基序)配体19(CCL19/ECL)是这个受体的特异性配体。这个受体介导的信号调节淋巴结中T细胞的稳态,也可能在T细胞的激活和极化以及慢性炎症发病机制中发挥作用。这个基因的可变剪接导致多个转录变异体。[RefSeq,2014年9月提供]
Related ID:
NCBI:1236
ENSEMBL:ENSG00000126353
HGNC:1608
UNIPROT:P32248
OMIM:600242
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
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Reference
1236
5
3
11704 bp
42.87
11
--
9
5
CCR7 Genetics information (-)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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