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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
CCR5 - C-C Motif Chemokine Receptor 5
Alias:
CKR5
CCR-5
CD195
CKR-5
CCCKR5
CMKBR5
IDDM22
CC-CKR-5
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码β趋化因子受体家族的一员,预测是一个类似于G蛋白偶联受体的七跨膜蛋白。这个蛋白由T细胞和巨噬细胞表达,已知是巨噬细胞嗜性病毒(包括HIV)进入宿主细胞的重要共受体。这个基因的缺陷等位基因与HIV感染抵抗力有关。这个受体的配体包括单核细胞化学吸引蛋白2(MCP-2)、巨噬细胞炎性蛋白1α(MIP-1α)、巨噬细胞炎性蛋白1β(MIP-1β)和调节活化正常T细胞表达和分泌的蛋白(RANTES)。这个基因在早幼粒细胞系中的表达提示这个蛋白可能在粒细胞谱系增殖和分化中发挥作用。这个基因位于趋化因子受体基因簇区域。这个基因中的一个等位基因多态性导致功能和非功能等位基因;参考基因组代表功能等位基因。已经在这个基因中发现了编码相同蛋白质的两个转录变异体。[由RefSeq,2015年7月提供]
Related ID:
NCBI:1234
ENSEMBL:ENSG00000160791
HGNC:1606
UNIPROT:P51681
OMIM:601373
Basic Information
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MW (kDa)
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1234
3
2
6065 bp
40.52
22
4
9
39
CCR5 Genetics information (+)
GRCh38
Sequence Homology
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* This data comes from NCBI.
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