小鼠

C3 - complement component 3

Alias:
ASP
Plp
HSE-MSF
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码补体蛋白C3,在补体系统的经典途径、替代途径和凝集素激活途径中扮演重要角色。编码的前原蛋白经历多步加工,生成各种功能肽。缺乏编码蛋白的小鼠在感染后无法清除血流中的细菌,在过敏原诱导的肺过敏后显示气道高反应性和肺嗜酸性细胞增多,以及在IgG免疫复合物沉积后发生严重肺损伤。人类中编码蛋白的同源物的缺乏与对感染的易感性增加、年龄相关性黄斑变性和不典型溶血性尿毒症综合征的相关性。[由RefSeq,2015年3月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
2
41
24170 bp
186.48
14
15

C3 Genetics information (-)

GRCm39

Sequence Homology

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Sequence
Comparison
Al agent
Tutorials
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